MINIPRESS

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133rd st pharmacy inc

1473 Amsterdam Ave
New York ny 10027
(212)491-4911

$175.19

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475 Atlantic Ave
Brooklyn ny 11217
(718)637-2970

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231 S 3rd St
Brooklyn ny 11211
(718)502-6969

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danny's pharmacy ii

110 W End Ave
New York ny 10023
(212)362-0000

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north hudson community pharmacy

5301 Broadway
West New York nj 07093
(201)520-9364

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139 Centre Street
New York ny 10013
(646)838-6388

$175.69

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125 18th St
Jersey City nj 07310
(201)418-0585

$177.04

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909 Columbus Ave
New York ny 10025
(212)222-6388

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18 Elizabeth St
New York ny 10013
(212)571-0027

$177.84

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hudson pharmacy

65 08 Roosevelt Avenue
Woodside ny 11377
(347)448-6965

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2002 2nd Ave
New York ny 10029
(212)410-4410

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3506 30th Ave
Astoria ny 11103
(718)777-8544

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8 Baldwin Ave Ste B
Jersey City nj 07304
(201)451-4944

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echo care specialty pharmacy

260 Broadway
Brooklyn ny 11211
(718)782-3030

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132 Allen St
New York ny 10002
(212)529-4532

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1200 Harbor Blvd
Weehawken nj 07086
(201)330-8147

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cvs pharmacy #02919

126 Eighth Ave
New York ny 10011
(800)362-7828

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139 Flatbush Ave
Brooklyn ny 11217
(718)290-1110

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400 Park Place
Secaucus nj 07094
(201)325-9275

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apicha health center pharmacy

400 Broadway
New York ny 10013
(646)744-0994

$182.86

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154 9th Ave
New York ny 10011
(212)255-8000

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chronos pharmacy

31 04 35th St
Astoria ny 11106
(718)932-8700

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55 Columbia St
New York ny 10002
(212)533-8120

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3510 Bergenline Ave
Union City nj 07087
(201)500-9366

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costco pharmacy #1062

517 E 117th St
New York ny 10035
(212)896-5882

$182.86

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pollock & bailey pharmacy

1032 1st Ave
New York ny 10022
(212)755-4244

$182.86

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534 Hudson Street
New York ny 10014
(646)486-1048

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ror madison pharmacy inc

1636 Madison Ave
New York ny 10029
(212)369-0700

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rx center

2325 1st Ave
New York ny 10035
(212)289-8839

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siri pharmacy inc

23 Flat Bush Ave
Brooklyn ny 11217
(718)596-7397

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st johns pharmacy

2980 John F Kennedy Blvd
Jersey City nj 07306
(201)963-3617

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3519 31st Ave
Astoria ny 11106
(718)267-8063

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901 2nd Ave
New York ny 10017
(212)752-5151

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umr pharmacy & surgical inc

437 Central Ave
Jersey City nj 07307
(201)418-0009

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29 W 116th St
New York ny 10026
(212)519-8346

$187.74

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optumrx pharmacy 706, inc.

30 30 47th Avenue
Long Island City ny 11101
(866)903-4466

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Pregnancy

Usage in Pregnancy MINIPRESS has been shown to be associated with decreased litter size at birth, 1, 4, and 21 days of age in rats when given doses more than 225 times the usual maximum recommended human dose. No evidence of drug-related external, visceral, or skeletal fetal abnormalities were observed. No drug-related external, visceral, or skeletal abnormalities were observed in fetuses of pregnant rabbits and pregnant monkeys at doses more than 225 times and 12 times the usual maximum recommended human dose, respectively. The use of prazosin and a beta-blocker for the control of severe hypertension in 44 pregnant women revealed no drug-related fetal abnormalities or adverse effects. Therapy with prazosin was continued for as long as 14 weeks.1 Prazosin has also been used alone or in combination with other hypotensive agents in severe hypertension of pregnancy by other investigators. No fetal or neonatal abnormalities have been reported with the use of prazosin.2 There are no adequate and well controlled studies which establish the safety of MINIPRESS in pregnant women. MINIPRESS should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and fetus.

Drug Interactions

Drug Interactions MINIPRESS has been administered without any adverse drug interaction in limited clinical experience to date with the following: (1) cardiac glycosides–digitalis and digoxin; (2) hypoglycemics–insulin, chlorpropamide, phenformin, tolazamide, and tolbutamide; (3) tranquilizers and sedatives–chlordiazepoxide, diazepam, and phenobarbital; (4) antigout–allopurinol, colchicine, and probenecid; (5) antiarrhythmics–procainamide, propranolol (see WARNINGS however), and quinidine; and (6) analgesics, antipyretics and anti-inflammatories–propoxyphene, aspirin, indomethacin, and phenylbutazone. Addition of a diuretic or other antihypertensive agent to MINIPRESS has been shown to cause an additive hypotensive effect. This effect can be minimized by reducing the MINIPRESS dose to 1 to 2 mg three times a day, by introducing additional antihypertensive drugs cautiously, and then by retitrating MINIPRESS based on clinical response. Concomitant administration of MINIPRESS with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension (see DOSAGE AND ADMINISTRATION).

Indications And Usage

INDICATIONS AND USAGE MINIPRESS is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including this drug. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. For specific advice on goals and management, see published guidelines, such as those of the National High Blood Pressure Education Program's Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC). Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal. Some antihypertensive drugs have smaller blood pressure effects (as monotherapy) in black patients, and many antihypertensive drugs have additional approved indications and effects (e.g., on angina, heart failure, or diabetic kidney disease). These considerations may guide selection of therapy. MINIPRESS can be used alone or in combination with other antihypertensive drugs such as diuretics or beta-adrenergic blocking agents.

Overdosage

OVERDOSAGE Accidental ingestion of at least 50 mg of MINIPRESS in a two year old child resulted in profound drowsiness and depressed reflexes. No decrease in blood pressure was noted. Recovery was uneventful. Should overdosage lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, shock should first be treated with volume expanders. If necessary, vasopressors should then be used. Renal function should be monitored and supported as needed. Laboratory data indicate MINIPRESS is not dialysable because it is protein bound.

Adverse Reactions

ADVERSE REACTIONS Clinical trials were conducted on more than 900 patients. During these trials and subsequent marketing experience, the most frequent reactions associated with MINIPRESS therapy are: dizziness 10.3%, headache 7.8%, drowsiness 7.6%, lack of energy 6.9%, weakness 6.5%, palpitations 5.3%, and nausea 4.9%. In most instances, side effects have disappeared with continued therapy or have been tolerated with no decrease in dose of drug. Less frequent adverse reactions which are reported to occur in 1–4% of patients are: Gastrointestinal: vomiting, diarrhea, constipation. Cardiovascular: edema, orthostatic hypotension, dyspnea, syncope. Central Nervous System: vertigo, depression, nervousness. Dermatologic: rash. Genitourinary: urinary frequency. EENT: blurred vision, reddened sclera, epistaxis, dry mouth, nasal congestion. In addition, fewer than 1% of patients have reported the following (in some instances, exact causal relationships have not been established): Gastrointestinal: abdominal discomfort and/or pain, liver function abnormalities, pancreatitis. Cardiovascular: tachycardia. Central Nervous System: paresthesia, hallucinations. Dermatologic: pruritus, alopecia, lichen planus. Genitourinary: incontinence, impotence, priapism. EENT: tinnitus. Other: diaphoresis, fever, positive ANA titer, arthralgia. Single reports of pigmentary mottling and serous retinopathy, and a few reports of cataract development or disappearance have been reported. In these instances, the exact causal relationship has not been established because the baseline observations were frequently inadequate. In more specific slit-lamp and funduscopic studies, which included adequate baseline examinations, no drug-related abnormal ophthalmological findings have been reported. Literature reports exist associating MINIPRESS therapy with a worsening of pre-existing narcolepsy. A causal relationship is uncertain in these cases. In post-marketing experience, the following adverse events have been reported: Autonomic Nervous System: flushing. Body As A Whole: allergic reaction, asthenia, malaise, pain. Cardiovascular, General: angina pectoris, hypotension. Endocrine: gynecomastia. Heart Rate/Rhythm: bradycardia. Psychiatric: insomnia. Skin/Appendages: urticaria. Vascular (Extracardiac): vasculitis. Vision: eye pain. Special Senses: During cataract surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris Syndrome (IFIS) has been reported in association with alpha-1 blocker therapy (see PRECAUTIONS).

Contraindications

CONTRAINDICATIONS MINIPRESS is contraindicated in patients with known sensitivity to quinazolines, prazosin, or any of the inert ingredients.

Nursing Mothers

Nursing Mothers MINIPRESS has been shown to be excreted in small amounts in human milk. Caution should be exercised when MINIPRESS is administered to a nursing woman.